Human SBF2/MTMR13 protein (Recombinant) (N-GST & C-His) (STJP008498)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SBF2/MTMR13-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SBF2 |
| Gene ID | 81846 |
| Uniprot ID | MTMRD_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly775-Glu882 |
Additional Info
| Function | Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate. |
| Protein Name | Myotubularin-Related Protein 13Inactive Phosphatidylinositol 3-Phosphatase 13Set-Binding Factor 2 |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinEndosome MembraneCell ProjectionAxonAssociated With MembranesLocalizes To Vacuoles In Hypo-Osmotic ConditionsMembrane Localization Is Likely To Be Mediated Via Its Interaction With Mtmr2 |
| Alternative Protein Names | Myotubularin-Related Protein 13 proteinInactive Phosphatidylinositol 3-Phosphatase 13 proteinSet-Binding Factor 2 proteinSBF2 proteinCMT4B2 proteinKIAA1766 proteinMTMR13 protein |
Information sourced from Uniprot.org