Human SARS1 protein (Recombinant) (N-His) (STJP015770)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SARS1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SARS1 |
| Gene ID | 6301 |
| Uniprot ID | SYSC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser142-Lys472 |
Additional Info
| Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. |
| Protein Name | Serine--Trna Ligase - CytoplasmicSeryl-Trna SynthetaseSerrsSeryl-Trna(Ser/Sec Synthetase |
| Database Links | Reactome: R-HSA-2408557Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicBut A Minor Proportion Is Also Found In The Nucleus |
| Alternative Protein Names | Serine--Trna Ligase - Cytoplasmic proteinSeryl-Trna Synthetase proteinSerrs proteinSeryl-Trna(Ser/Sec Synthetase proteinSARS1 proteinSARS proteinSERS protein |
Information sourced from Uniprot.org