Human SARS protein (Recombinant) (His-Tag) (STJP017480)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SARS1 |
| Gene ID | 6301 |
| Uniprot ID | SYSC_HUMAN |
| Accession Number | NP_006504 |
| Immunogen | Human |
| Immunogen Region | 1-514aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Brain. |
| Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. |
| Protein Name | Serine--Trna Ligase - CytoplasmicSeryl-Trna SynthetaseSerrsSeryl-Trna(Ser/Sec Synthetase |
| Database Links | Reactome: R-HSA-2408557Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicBut A Minor Proportion Is Also Found In The Nucleus |
| Alternative Protein Names | Serine--Trna Ligase - Cytoplasmic proteinSeryl-Trna Synthetase proteinSerrs proteinSeryl-Trna(Ser/Sec Synthetase proteinSARS1 proteinSARS proteinSERS protein |
Information sourced from Uniprot.org