Human RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018347)
SPECIFICATIONS
General Information
| Short Description | This RYR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.27ng/mL |
| Detection Limit | 0.781-50ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | RYR1 |
| Gene ID | 6261 |
| Uniprot ID | RYR1_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Skeletal muscle and brain (cerebellum and hippocampus). |
| Post Translational Modifications | Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation. |
| Function | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis. |
| Protein Name | Ryanodine Receptor 1Ryr-1Ryr1Skeletal Muscle Calcium Release ChannelSkeletal Muscle Ryanodine ReceptorSkeletal Muscle-Type Ryanodine ReceptorType 1 Ryanodine Receptor |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneMulti-Pass Membrane ProteinThe Number Of Predicted Transmembrane Domains Varies Between OrthologsBoth N-Terminus And C-Terminus Are Cytoplasmic |
| Alternative ELISA Names | Ryanodine Receptor 1 ELISA kitRyr-1 ELISA kitRyr1 ELISA kitSkeletal Muscle Calcium Release Channel ELISA kitSkeletal Muscle Ryanodine Receptor ELISA kitSkeletal Muscle-Type Ryanodine Receptor ELISA kitType 1 Ryanodine Receptor ELISA kitRYR1 ELISA kitRYDR ELISA kit |
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Information sourced from Uniprot.org