Human RRM2B protein (Recombinant) (N-His) (STJP005626)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RRM2B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RRM2B |
| Gene ID | 50484 |
| Uniprot ID | RIR2B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Phe351 |
Additional Info
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2 BTp53-Inducible Ribonucleotide Reductase M2 BP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like ProteinP53r2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-5628897 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus In Response To Dna Damage |
| Alternative Protein Names | Ribonucleoside-Diphosphate Reductase Subunit M2 B proteinTp53-Inducible Ribonucleotide Reductase M2 B proteinP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein proteinP53r2 proteinRRM2B proteinP53R2 protein |
Information sourced from Uniprot.org