Human RRM2 protein (Recombinant) (His-Tag) (STJP016722)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RRM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRM2 |
| Gene ID | 6241 |
| Uniprot ID | RIR2_HUMAN |
| Accession Number | NP_001025.1 |
| Immunogen | Human |
| Immunogen Region | 1-389aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2.predominantly in G2 and M phase. Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex.leading to its degradation by the proteasome. |
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2Ribonucleotide Reductase Small ChainRibonucleotide Reductase Small Subunit |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-69205Reactome: R-HSA-8953750 |
| Cellular Localisation | CytoplasmNucleusLocalized To The Cytoplasm In S Phase CellsMay Localize To The Nucleus In G2 Phase Cells |
| Alternative Protein Names | Ribonucleoside-Diphosphate Reductase Subunit M2 proteinRibonucleotide Reductase Small Chain proteinRibonucleotide Reductase Small Subunit proteinRRM2 proteinRR2 protein |
Information sourced from Uniprot.org