Human RQCD1/CNOT9 protein (Recombinant) (His-Tag) (STJP016927)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RQCD1/CNOT9-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNOT9 |
| Gene ID | 9125 |
| Uniprot ID | CNOT9_HUMAN |
| Accession Number | NP_005435 |
| Immunogen | Human |
| Immunogen Region | 1-299aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in spleen, thymus, prostate, testis, ovary and intestine. |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 9Cell Differentiation Protein Rqcd1 HomologRcd-1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-5617472Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | NucleusCytoplasmP-BodyNanos2 Promotes Its Localization To P-Body |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 9 proteinCell Differentiation Protein Rqcd1 Homolog proteinRcd-1 proteinCNOT9 proteinRCD1 proteinRQCD1 protein |
Information sourced from Uniprot.org