Human RNF43 protein (Recombinant) (C-hFC) (STJP020349)

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STJP020349
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: RNF43
Gene ID: 54894
Uniprot ID: RNF43_HUMAN
Immunogen Region: Gly24-Tyr197
Immunogen: Recombinant Human RNF43 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Tyr197) of human RNF43 (Accession #NP_001292473.1) fused with a hFc tag at the C-terminus.
Immunogen Sequence: GFGRTGLVLAAAVESERSAE QKAIIRVIPLKMDPTGKLNL TLEGVFAGVAEITPAEGKLM QSHPLYLCNASDDDNLEPGF ISIVKLESPRRAPRPCLSLA SKARMAGERGASAVLFDITE DRAAAEQLQQPLGLTWPVVL IWGNDAEKLMEFVYKNQKAH VRIELKEPPAWPDY
Tissue Specificity Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Post Translational Modifications Autoubiquitinated.
Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
Protein Name E3 Ubiquitin-Protein Ligase Rnf43
Ring Finger Protein 43
Ring-Type E3 Ubiquitin Transferase Rnf43
Database Links Reactome: R-HSA-4641263
Reactome: R-HSA-5340588
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus Envelope
According To A Report
May Be Secreted
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rnf43 protein
Ring Finger Protein 43 protein
Ring-Type E3 Ubiquitin Transferase Rnf43 protein
RNF43 protein

Information sourced from Uniprot.org

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