Human RNF220 protein (Recombinant) (N-GST & C-His) (STJP015895)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RNF220-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | RNF220 |
| Gene ID | 55182 |
| Uniprot ID | RN220_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys482-Leu566 |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated.leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf220Ring Finger Protein 220Ring-Type E3 Ubiquitin Transferase Rnf220 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rnf220 proteinRing Finger Protein 220 proteinRing-Type E3 Ubiquitin Transferase Rnf220 proteinRNF220 proteinC1orf164 protein |
Information sourced from Uniprot.org