Human RNASE6 (Ribonuclease A6) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018300)

Name: Human RNASE6 (Ribonuclease A6) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018300)
SKU: STJE0018300
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SPECIFICATIONS

STJE0018300

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Short Description	This RNASE6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Applications	ELISA
Reactivity	Human
Sensitivity	0.064ng/mL
Detection Limit	0.156-10ng/mL
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Storage Instruction	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time	3 hrs

Gene Symbol	RNASE6
Gene ID	6039
Uniprot ID	RNAS6_HUMAN
Immunogen Region	Ready-To-Use
Sample Type	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Highly expressed in spleen (at protein level). Has little or no expression in healthy kidneys (at protein level). Detected in interstitial leukocytes in infected kidneys (at protein level). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
Post Translational Modifications
Function	Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Protein Name	Ribonuclease K6 Rnase K6
Database Links	Reactome: R-HSA-6803157
Cellular Localisation	Secreted Lysosome Cytoplasmic Granule
Alternative ELISA Names	Ribonuclease K6 ELISA kit Rnase K6 ELISA kit RNASE6 ELISA kit RNS6 ELISA kit
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Information sourced from Uniprot.org