Human RNA polymerases I, II, and III subunit RPABC2/POLR2F protein (Recombinant) (His-Tag) (STJP018744)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Rpolymerases I, II, and III subunit RPABC2/POLR2F-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POLR2F |
| Gene ID | 5435 |
| Uniprot ID | RPAB2_HUMAN |
| Accession Number | NP_068809 |
| Immunogen | Human |
| Immunogen Region | 1-127aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSDNEDN FDGDDFDDVE EDEGLDDLEN AEEEGQENVE ILPSGERPQA NQKRITTPYM TKYERARVLG TRALQIAMCA PVMVELEGET DPLLIAMKEL KARKIPIIIR RYLPDGSYED WGVDELIITD |
Additional Info
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds. |
| Protein Name | Dna-Directed Rna Polymerases I - Ii - And Iii Subunit Rpabc2Rna Polymerases I - Ii - And Iii Subunit Abc2Dna-Directed Rna Polymerase Ii Subunit FDna-Directed Rna Polymerases I - Ii - And Iii 14.4 Kda PolypeptideRpabc14.4Rpb14.4Rpb6 HomologRpc15 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-168325Reactome: R-HSA-1834949Reactome: R-HSA-203927Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-5578749Reactome: R-HSA-5601884Reactome: R-HSA-5617472Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-6803529Reactome: R-HSA-6807505Reactome: R-HSA-72086Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72203Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73780Reactome: R-HSA-73863Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071Reactome: R-HSA-77075Reactome: R-HSA-8851708Reactome: R-HSA-9018519Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | Dna-Directed Rna Polymerases I - Ii - And Iii Subunit Rpabc2 proteinRna Polymerases I - Ii - And Iii Subunit Abc2 proteinDna-Directed Rna Polymerase Ii Subunit F proteinDna-Directed Rna Polymerases I - Ii - And Iii 14.4 Kda Polypeptide proteinRpabc14.4 proteinRpb14.4 proteinRpb6 Homolog proteinRpc15 proteinPOLR2F proteinPOLRF protein |
Information sourced from Uniprot.org