Human RIOK3 protein (Recombinant) (N-His) (STJP008338)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RIOK3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RIOK3 |
| Gene ID | 8780 |
| Uniprot ID | RIOK3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser247-Glu519 |
Additional Info
| Post Translational Modifications | Autophosphorylated (in vitro). |
| Function | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. |
| Protein Name | Serine/Threonine-Protein Kinase Rio3Rio Kinase 3Sudd Homolog |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Rio3 proteinRio Kinase 3 proteinSudd Homolog proteinRIOK3 proteinSUDD protein |
Information sourced from Uniprot.org