Human REXO2 protein (Recombinant) (N-His) (STJP006256)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human REXO2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | REXO2 |
| Gene ID | 25996 |
| Uniprot ID | ORN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln41-Asn213 |
Additional Info
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. |
| Protein Name | Oligoribonuclease - MitochondrialRna Exonuclease 2 HomologSmall Fragment Nuclease |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixMitochondrionCytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative Protein Names | Oligoribonuclease - Mitochondrial proteinRna Exonuclease 2 Homolog proteinSmall Fragment Nuclease proteinREXO2 proteinSFN proteinSMFN proteinCGI-114 protein |
Information sourced from Uniprot.org