Human REG3A protein (Recombinant) (N-His) (STJP005197)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human REG3A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | REG3A |
| Gene ID | 5068 |
| Uniprot ID | REG3A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys40-Asn164 |
Additional Info
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Regenerating islet-derived protein 3-alpha 15 kDa form: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. Regenerating islet-derived protein 3-alpha 16.5 kDa form: Has bacteriostatic activity. |
| Protein Name | Regenerating Islet-Derived Protein 3-AlphaReg-3-AlphaHepatointestinal Pancreatic ProteinHip/PapHuman Proislet PeptideHipPancreatitis-Associated Protein 1Regenerating Islet-Derived Protein Iii-AlphaReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedFound In The Apical Region Of Pancreatic Acinar Cells |
| Alternative Protein Names | Regenerating Islet-Derived Protein 3-Alpha proteinReg-3-Alpha proteinHepatointestinal Pancreatic Protein proteinHip/Pap proteinHuman Proislet Peptide proteinHip proteinPancreatitis-Associated Protein 1 proteinRegenerating Islet-Derived Protein Iii-Alpha proteinReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form proteinREG3A proteinHIP proteinPAP proteinPAP1 protein |
Information sourced from Uniprot.org