Human REC8 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007608)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human REC8-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | REC8 |
| Gene ID | 9985 |
| Uniprot ID | REC8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu470-His547 |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. |
| Protein Name | Meiotic Recombination Protein Rec8 HomologCohesin Rec8p |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereIn Meiotic ChromosomesLocalized Along Axial Elements In Prophase From The Leptotene To Diplotene StagesAt Later Prophase StagesDiakinesis And Metaphase ILocalized Along Interstitial Axes Of Chromosomes Including Both Centromere And Arm RegionsNo Longer Detected In Arm Regions In Anaphase I But Persists On Centromere Regions Until Metaphase IiLocalized To Centromeres And Spindle Poles In Endopolyploid Tumor Cells |
| Alternative Protein Names | Meiotic Recombination Protein Rec8 Homolog proteinCohesin Rec8p proteinREC8 proteinREC8L1 protein |
Information sourced from Uniprot.org