Human RCOR1 protein (Recombinant) (N-His) (STJP007925)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RCOR1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RCOR1 |
| Gene ID | 23186 |
| Uniprot ID | RCOR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn141-Glu266 |
Additional Info
| Post Translational Modifications | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Protein Name | Rest Corepressor 1Protein Corest |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusUpon Infection By Hsv-1It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Protein Names | Rest Corepressor 1 proteinProtein Corest proteinRCOR1 proteinKIAA0071 proteinRCOR protein |
Information sourced from Uniprot.org