Human RCHY1 protein (Recombinant) (His-Tag) (STJP018293)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RCHY1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCHY1 |
| Gene ID | 25898 |
| Uniprot ID | ZN363_HUMAN |
| Accession Number | NP_056251 |
| Immunogen | Human |
| Immunogen Region | 1-261aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53.preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation. Isoform 4: Has no E3 ubiquitin-protein ligase activity. |
| Protein Name | Ring Finger And Chy Zinc Finger Domain-Containing Protein 1Androgen Receptor N-Terminal-Interacting ProteinCh-Rich-Interacting Match With Plag1E3 Ubiquitin-Protein Ligase Pirh2Ring Finger Protein 199Ring-Type E3 Ubiquitin Transferase Rchy1Zinc Finger Protein 363P53-Induced Ring-H2 ProteinHpirh2 |
| Database Links | Reactome: R-HSA-110320Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Protein Names | Ring Finger And Chy Zinc Finger Domain-Containing Protein 1 proteinAndrogen Receptor N-Terminal-Interacting Protein proteinCh-Rich-Interacting Match With Plag1 proteinE3 Ubiquitin-Protein Ligase Pirh2 proteinRing Finger Protein 199 proteinRing-Type E3 Ubiquitin Transferase Rchy1 proteinZinc Finger Protein 363 proteinP53-Induced Ring-H2 Protein proteinHpirh2 proteinRCHY1 proteinARNIP proteinCHIMP proteinPIRH2 proteinRNF199 proteinZNF363 protein |
Information sourced from Uniprot.org