Human RBM39 protein (Recombinant) (N-His) (STJP007810)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RBM39-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RBM39 |
| Gene ID | 9584 |
| Uniprot ID | RBM39_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr146-Val326 |
Additional Info
| Post Translational Modifications | Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex. RBM39 degradation results in splicing defects and death in cancer cell lines. Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39. |
| Function | RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity. |
| Protein Name | Rna-Binding Protein 39Caper AlphaCaperalphaHepatocellular Carcinoma Protein 1Rna-Binding Motif Protein 39Rna-Binding Region-Containing Protein 2Splicing Factor Hcc1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleConcentrated In Nuclear SpecklesColocalizes With The Core Spliceosomal Snrnp Proteins |
| Alternative Protein Names | Rna-Binding Protein 39 proteinCaper Alpha proteinCaperalpha proteinHepatocellular Carcinoma Protein 1 proteinRna-Binding Motif Protein 39 proteinRna-Binding Region-Containing Protein 2 proteinSplicing Factor Hcc1 proteinRBM39 proteinHCC1 proteinRNPC2 protein |
Information sourced from Uniprot.org