Human RBM25 protein (Recombinant) (N-His) (STJP016149)

Name: Human RBM25 protein (Recombinant) (N-His) (STJP016149)
SKU: STJP016149
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP016149

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Short Description	Recombinant-Human RBM25-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	Please contact us for further information.

Function	RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Protein Name	Rna-Binding Protein 25 Arg/Glu/Asp-Rich Protein Of 120 Kda Red120 Protein S164 Rna-Binding Motif Protein 25 Rna-Binding Region-Containing Protein 7
Database Links	Reactome: R-HSA-72163
Cellular Localisation	Nucleus Speckle Cytoplasm Colocalizes Predominantly With Sfrs2 And Luc7l3 Splicing Factors In Nuclear Speckles Cytoplasmic Localization Is Faint
Alternative Protein Names	Rna-Binding Protein 25 protein Arg/Glu/Asp-Rich Protein Of 120 Kda protein Red120 protein Protein S164 protein Rna-Binding Motif Protein 25 protein Rna-Binding Region-Containing Protein 7 protein RBM25 protein RNPC7 protein

Information sourced from Uniprot.org