Human RB1CC1 protein (Recombinant) (N-His) (STJP007340)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RB1CC1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RB1CC1 |
| Gene ID | 9821 |
| Uniprot ID | RBCC1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu1447-Val1594 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-734 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. |
| Function | Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. |
| Protein Name | Rb1-Inducible Coiled-Coil Protein 1Fak Family Kinase-Interacting Protein Of 200 KdaFip200 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | NucleusCytoplasmCytosolPreautophagosomal StructureLysosomeUnder Starvation ConditionsIs Localized To Puncate Structures Primarily Representing The Isolation Membrane That Sequesters A Portion Of The Cytoplasm Resulting In The Formation Of An Autophagosome |
| Alternative Protein Names | Rb1-Inducible Coiled-Coil Protein 1 proteinFak Family Kinase-Interacting Protein Of 200 Kda proteinFip200 proteinRB1CC1 proteinKIAA0203 proteinRBICC protein |
Information sourced from Uniprot.org