Human RAC3 protein (Recombinant) (N-His) (STJP009628)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RAC3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RAC3 |
| Gene ID | 5881 |
| Uniprot ID | RAC3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Phe192 |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. Ubiquitinated at Lys-166 in a FBXL19-mediated manner.leading to proteasomal degradation. |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. |
| Protein Name | Ras-Related C3 Botulinum Toxin Substrate 3P21-Rac3 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmEndomembrane SystemCell ProjectionLamellipodiumPerinuclear RegionCell MembraneCytoskeletonMembrane-Associated When ActivatedColocalizes With Nrbp To Endomembranes And At The Cell Periphery In LamellipodiaColocalized With Cib1 In The Perinuclear Area And At The Cell Periphery |
| Alternative Protein Names | Ras-Related C3 Botulinum Toxin Substrate 3 proteinP21-Rac3 proteinRAC3 protein |
Information sourced from Uniprot.org