| Post Translational Modifications | (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. Ubiquitinated at Lys-166 in a FBXL19-mediated manner.leading to proteasomal degradation. |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. |
| Protein Name | Ras-Related C3 Botulinum Toxin Substrate 3P21-Rac3 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmEndomembrane SystemCell ProjectionLamellipodiumPerinuclear RegionCell MembraneCytoskeletonMembrane-Associated When ActivatedColocalizes With Nrbp To Endomembranes And At The Cell Periphery In LamellipodiaColocalized With Cib1 In The Perinuclear Area And At The Cell Periphery |
| Alternative Protein Names | Ras-Related C3 Botulinum Toxin Substrate 3 proteinP21-Rac3 proteinRAC3 protein |
Information sourced from Uniprot.org
