Human RAB6A protein (Recombinant) (His-Tag) (STJP016969)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB6A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB6A |
| Gene ID | 5870 |
| Uniprot ID | RAB6A_HUMAN |
| Accession Number | NP_002860.2 |
| Immunogen | Human |
| Immunogen Region | 1-208aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Prenylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development (Probable). |
| Protein Name | Ras-Related Protein Rab-6aRab-6 |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-6811440Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic VesicleSecretory VesicleAcrosome MembranePeripheral Membrane ProteinBicd2 Facilitates Its Targeting To Golgi Apparatus MembraneIsoform 1: Golgi Apparatus MembraneIsoform 2: Golgi Apparatus Membrane |
| Alternative Protein Names | Ras-Related Protein Rab-6a proteinRab-6 proteinRAB6A proteinRAB6 protein |
Information sourced from Uniprot.org