Human RAB3IP protein (Recombinant) (N-His) (STJP008298)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RAB3IP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RAB3IP |
| Gene ID | 117177 |
| Uniprot ID | RAB3I_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp314-Leu476 |
Additional Info
| Post Translational Modifications | Phosphorylated by AKT1.the phosphorylation alters its GEF activity. |
| Function | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. |
| Protein Name | Rab-3a-Interacting ProteinRab3a-Interacting ProteinRabin-3Rabin8Ssx2-Interacting Protein |
| Database Links | Reactome: R-HSA-5620912Reactome: R-HSA-5620916Reactome: R-HSA-5620922Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonCell ProjectionLamellipodiumVesicleMicrotubule Organizing CenterCentrosomePredominantly Cytoplasmic But A Small Proportion Colocalizes With Ssx2 In The NucleusActivation Of Protein Kinase C Results In Redistribution To The Periphery Of Lamellipodia |
| Alternative Protein Names | Rab-3a-Interacting Protein proteinRab3a-Interacting Protein proteinRabin-3 proteinRabin8 proteinSsx2-Interacting Protein proteinRAB3IP proteinRABIN8 protein |
Information sourced from Uniprot.org