Human RAB39B protein (Recombinant) (N-His) (STJP010325)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RAB39B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RAB39B |
| Gene ID | 116442 |
| Uniprot ID | RB39B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe97-Arg209 |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39B is involved in autophagy and may function in autophagosome formation. Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission. May regulate the homeostasis of SNCA/alpha-synuclein. |
| Protein Name | Ras-Related Protein Rab-39b |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic Vesicle MembraneGolgi ApparatusCytoplasmic VesicleAutophagosome MembraneAutolysosome MembranePartial Colocalization With Markers That Cycle From The Cell Surface To The Trans-Golgi NetworkColocalized With Stx17 In Autolysosomes In Autophagy-Induced ConditionsAlthough Less Compared With Rab39a |
| Alternative Protein Names | Ras-Related Protein Rab-39b proteinRAB39B protein |
Information sourced from Uniprot.org