Human RAB27A protein (Recombinant) (His-Tag) (STJP016696)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB27A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB27A |
| Gene ID | 5873 |
| Uniprot ID | RB27A_HUMAN |
| Accession Number | NP_899059 |
| Immunogen | Human |
| Immunogen Region | 1-221aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. |
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. |
| Protein Name | Ras-Related Protein Rab-27aRab-27Gtp-Binding Protein Ram |
| Database Links | Reactome: R-HSA-264876Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8876198Reactome: R-HSA-9824585 |
| Cellular Localisation | MembraneLipid-AnchorMelanosomeLate EndosomeLysosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvLocalizes To Endosomal Exocytic Vesicles |
| Alternative Protein Names | Ras-Related Protein Rab-27a proteinRab-27 proteinGtp-Binding Protein Ram proteinRAB27A proteinRAB27 protein |
Information sourced from Uniprot.org