Human RAB21 protein (Recombinant) (His-Tag) (STJP017045)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB21-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 200mM NaCl, 1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB21 |
| Gene ID | 23011 |
| Uniprot ID | RAB21_HUMAN |
| Accession Number | NP_055814.1 |
| Immunogen | Human |
| Immunogen Region | 18-222aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10. |
| Protein Name | Ras-Related Protein Rab-21 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneLipid-AnchorGolgi ApparatusTrans-Golgi NetworkGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmic Vesicle MembraneCleavage FurrowCell ProjectionNeuron ProjectionColocalizes With Ankrd27 And Vamp7 In NeuritesIn Nonpolarized Epithelial Caco-2 CellsFound In The Endoplasmic ReticulumIn Polarized CellsObserved In Vesicles In The Apical CytoplasmDuring MitosisIn Mid-TelophaseLocalized In The Ingressing Cleavage FurrowIn Late TelophaseDetected At The Opposite Poles Of The Daughter CellsIn Vesicles At The Base Of Lamellipodia Formed By The Separating Daughter Cells |
| Alternative Protein Names | Ras-Related Protein Rab-21 proteinRAB21 proteinKIAA0118 protein |
Information sourced from Uniprot.org