Human RAB18 protein (Recombinant) (T7-Tag) (STJP017413)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB18-T7-Tag protein was developed from e.coli and has a target region of T7-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB18 |
| Gene ID | 22931 |
| Uniprot ID | RAB18_HUMAN |
| Accession Number | NP_067075.1 |
| Immunogen | Human |
| Immunogen Region | 1-206aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration. |
| Protein Name | Ras-Related Protein Rab-18 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneGolgi ApparatusCis-Golgi Network MembraneLipid DropletApical Cell MembraneLocalized To The Er Membrane As Well As To The Cis-Golgi In Fibroblasts |
| Alternative Protein Names | Ras-Related Protein Rab-18 proteinRAB18 protein |
Information sourced from Uniprot.org