Human RAB18 protein (Recombinant) (N-His) (STJP007595)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RAB18-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RAB18 |
| Gene ID | 22931 |
| Uniprot ID | RAB18_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys183 |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration. |
| Protein Name | Ras-Related Protein Rab-18 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneGolgi ApparatusCis-Golgi Network MembraneLipid DropletApical Cell MembraneLocalized To The Er Membrane As Well As To The Cis-Golgi In Fibroblasts |
| Alternative Protein Names | Ras-Related Protein Rab-18 proteinRAB18 protein |
Information sourced from Uniprot.org