Human PTPRU protein (Recombinant) (N-His) (STJP006686)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PTPRU-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PTPRU |
| Gene ID | 10076 |
| Uniprot ID | PTPRU_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg1263-Arg1446 |
Additional Info
| Post Translational Modifications | The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase UR-Ptp-UPancreatic Carcinoma Phosphatase 2Pcp-2Protein-Tyrosine Phosphatase JPtp-JHptp-JProtein-Tyrosine Phosphatase PiPtp PiProtein-Tyrosine Phosphatase Receptor OmicronPtp-RoReceptor-Type Protein-Tyrosine Phosphatase PsiR-Ptp-Psi |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase U proteinR-Ptp-U proteinPancreatic Carcinoma Phosphatase 2 proteinPcp-2 proteinProtein-Tyrosine Phosphatase J proteinPtp-J proteinHptp-J proteinProtein-Tyrosine Phosphatase Pi proteinPtp Pi proteinProtein-Tyrosine Phosphatase Receptor Omicron proteinPtp-Ro proteinReceptor-Type Protein-Tyrosine Phosphatase Psi proteinR-Ptp-Psi proteinPTPRU proteinFMI proteinPCP2 proteinPTPRO protein |
Information sourced from Uniprot.org