Human PTPN4 protein (Recombinant) (N-His) (STJP015803)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PTPN4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | PTPN4 |
| Gene ID | 5775 |
| Uniprot ID | PTN4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp636-Lys926 |
Additional Info
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 4Protein-Tyrosine Phosphatase Meg1MegPtpase-Meg1 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-9008059Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeleton |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type 4 proteinProtein-Tyrosine Phosphatase Meg1 proteinMeg proteinPtpase-Meg1 proteinPTPN4 protein |
Information sourced from Uniprot.org