| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PTPN11-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | PTPN11 |
| Gene ID: | 5781 |
| Uniprot ID: | PTN11_HUMAN |
| Immunogen Region: | Met1-Arg593 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA. Phosphorylated by activated PDGFRB. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11Protein-Tyrosine Phosphatase 1dPtp-1dProtein-Tyrosine Phosphatase 2cPtp-2cSh-Ptp2Shp-2Shp2Sh-Ptp3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-109704Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-114604Reactome: R-HSA-1170546Reactome: R-HSA-1257604Reactome: R-HSA-1295596Reactome: R-HSA-1433557Reactome: R-HSA-180292Reactome: R-HSA-186763Reactome: R-HSA-210990Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2586552Reactome: R-HSA-388841Reactome: R-HSA-389513Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-418886Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6811558Reactome: R-HSA-877312Reactome: R-HSA-8853659Reactome: R-HSA-8854691Reactome: R-HSA-8865999Reactome: R-HSA-8934593Reactome: R-HSA-9008059Reactome: R-HSA-9028731Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-936964Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703648Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type 11 proteinProtein-Tyrosine Phosphatase 1d proteinPtp-1d proteinProtein-Tyrosine Phosphatase 2c proteinPtp-2c proteinSh-Ptp2 proteinShp-2 proteinShp2 proteinSh-Ptp3 proteinPTPN11 proteinPTP2C proteinSHPTP2 protein |
Information sourced from Uniprot.org
