Human PSMA8 protein (Recombinant) (His-Tag) (STJP017444)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PSMA8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSMA8 |
| Gene ID | 143471 |
| Uniprot ID | PSMA8_HUMAN |
| Accession Number | NP_001020267 |
| Immunogen | Human |
| Immunogen Region | 1-250aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAGLTA DARVVINRAR VECQSHKLTV EDPVTVEYIT RFIATLKQKY TQSNGRRPFG ISALIVGFDD DGISRLYQTD PSGTYHAWKA NAIGRSAKTV REFLEKNYTE DAIASDSEAI KLAIKALLEV VQSGGKNI |
Additional Info
| Function | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. |
| Protein Name | Proteasome Subunit Alpha-Type 8Proteasome Alpha 4 SubunitAlpha4sProteasome Subunit Alpha-Type 7-Like |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | NucleusLocalizes To The Central Region Of The Synaptonemal Complex |
| Alternative Protein Names | Proteasome Subunit Alpha-Type 8 proteinProteasome Alpha 4 Subunit proteinAlpha4s proteinProteasome Subunit Alpha-Type 7-Like proteinPSMA8 proteinPSMA7L protein |
Information sourced from Uniprot.org