Human PRTN3 protein (Recombinant) (N-His) (STJP010186)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PRTN3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PRTN3 |
| Gene ID | 5657 |
| Uniprot ID | PRTN3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile28-Arg249 |
Additional Info
| Function | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation. |
| Protein Name | MyeloblastinAgp7C-Anca AntigenLeukocyte Proteinase 3Pr-3Pr3Neutrophil Proteinase 4Np-4P29Wegener Autoantigen |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-449836Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | Cytoplasmic GranuleSecretedCell MembranePeripheral Membrane ProteinExtracellular SideMembrane RaftLocalizes Predominantly To Azurophil Granules (Primary Secretory Granules) In NeutrophilsSecreted Upon Neutrophil Stimulation By Tnf-AlphaLipopolysaccharide (Lps)Fmlp And Cxcl8/Il8 Or During Neutrophil TransmigrationFollowing Secretion Tethered To The Cell Membrane By Cd177 |
| Alternative Protein Names | Myeloblastin proteinAgp7 proteinC-Anca Antigen proteinLeukocyte Proteinase 3 proteinPr-3 proteinPr3 proteinNeutrophil Proteinase 4 proteinNp-4 proteinP29 proteinWegener Autoantigen proteinPRTN3 proteinMBN protein |
Information sourced from Uniprot.org