Human PRSS2 protein (Recombinant-Active) (C-10*His) (STJP011817)

SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
STJP011817-100
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General Information

Short DescriptionRecombinant-Active-Human PRSS2-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications.
ApplicationsELISA/WB
HostMammalian Cells
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ConjugationUnconjugated
Dilution RangeReconstitute in sterile water for a stock solution.
FormulationLyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage InstructionUse a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin<0.1 EU/Mu g of the protein by the LAL method.
ImmunoreactivityMeasured by its ability to cleave the fluorogenic peptide substrate, McaRPKPVE-NvalWRK (Dnp)-NH2. The specific activity is >8, 000 pmol/min/µg, as measured under the described conditions.

Target Information

Gene SymbolPRSS2
Gene ID5645
Uniprot IDTRY2_HUMAN
ImmunogenHomo sapiens (Human)
Immunogen RegionAla16-Ser247

Additional Info

Post Translational Modifications Sulfated on tyrosine. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
Function In the ileum, may be involved in defensin processing, including DEFA5.
Protein Name Trypsin-2
Anionic Trypsinogen
Serine Protease 2
Trypsin Ii
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1462054
Reactome: R-HSA-1592389
Reactome: R-HSA-6798695
Reactome: R-HSA-6803157
Cellular Localisation Secreted
Extracellular Space
Alternative Protein Names Trypsin-2 protein
Anionic Trypsinogen protein
Serine Protease 2 protein
Trypsin Ii protein
PRSS2 protein
TRY2 protein
TRYP2 protein

Information sourced from Uniprot.org

Citations

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