Human PRMT3 protein (Recombinant) (His-Tag) (STJP019048)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PRMT3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRMT3 |
| Gene ID | 10196 |
| Uniprot ID | ANM3_HUMAN |
| Accession Number | NP_005779.1 |
| Immunogen | Human |
| Immunogen Region | 1-531aa |
| Immunogen Sequence |
Additional Info
| Function | Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases. Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2. Also appears to methylate other ribosomal proteins. May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation. Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis. |
| Protein Name | Protein Arginine N-Methyltransferase 3Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8876725 |
| Cellular Localisation | CytoplasmCytosolNucleusLocalized To The Nucleus By Znf200 |
| Alternative Protein Names | Protein Arginine N-Methyltransferase 3 proteinHeterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 proteinPRMT3 proteinHRMT1L3 protein |
Information sourced from Uniprot.org