Human PRKRA protein (Recombinant) (N-His) (STJP008154)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PRKRA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PRKRA |
| Gene ID | 8575 |
| Uniprot ID | PRKRA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn126-Lys313 |
Additional Info
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. |
| Protein Name | Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator APkr-Associated Protein XPkr-Associating Protein XProtein Activator Of The Interferon-Induced Protein KinaseProtein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator |
| Database Links | Reactome: R-HSA-203927Reactome: R-HSA-426486Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Protein Names | Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator A proteinPkr-Associated Protein X proteinPkr-Associating Protein X proteinProtein Activator Of The Interferon-Induced Protein Kinase proteinProtein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator proteinPRKRA proteinPACT proteinRAX proteinHSD-14 proteinHSD14 protein |
Information sourced from Uniprot.org