Human PRKG2 protein (Recombinant) (N-His) (STJP007959)

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STJP007959
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRKG2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRKG2
Gene ID: 5593
Uniprot ID: KGP2_HUMAN
Immunogen Region: Ser431-Phe762
Immunogen: Homo sapiens (Human)
Post Translational Modifications Myristoylation mediates membrane localization.
Function Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation.
Protein Name Cgmp-Dependent Protein Kinase 2
Cgk 2
Cgk2
Cgmp-Dependent Protein Kinase Ii
Cgkii
Database Links Reactome: R-HSA-1474151
Reactome: R-HSA-4086398
Reactome: R-HSA-418457
Reactome: R-HSA-9648002
Cellular Localisation Apical Cell Membrane
Lipid-Anchor
Alternative Protein Names Cgmp-Dependent Protein Kinase 2 protein
Cgk 2 protein
Cgk2 protein
Cgmp-Dependent Protein Kinase Ii protein
Cgkii protein
PRKG2 protein
PRKGR2 protein

Information sourced from Uniprot.org

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