Human PRDM1 protein (Recombinant) (N-His) (STJP003369)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PRDM1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PRDM1 |
| Gene ID | 639 |
| Uniprot ID | PRDM1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His493-Lys678 |
Additional Info
| Function | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1. |
| Protein Name | Pr Domain Zinc Finger Protein 1Blimp-1Beta-Interferon Gene Positive Regulatory Domain I-Binding FactorPr Domain-Containing Protein 1Positive Regulatory Domain I-Binding Factor 1Prdi-Bf1Prdi-Binding Factor 1 |
| Database Links | Reactome: R-HSA-6804754Reactome: R-HSA-9701898Reactome: R-HSA-9827857 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Pr Domain Zinc Finger Protein 1 proteinBlimp-1 proteinBeta-Interferon Gene Positive Regulatory Domain I-Binding Factor proteinPr Domain-Containing Protein 1 proteinPositive Regulatory Domain I-Binding Factor 1 proteinPrdi-Bf1 proteinPrdi-Binding Factor 1 proteinPRDM1 proteinBLIMP1 protein |
Information sourced from Uniprot.org