Human PR3 (Myeloblastin) Antibody Pair (STJAP00228)

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STJAP00228-50
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Host: Sheep/Sheep
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This PR3 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: PRTN3
Gene ID: 5657
Uniprot ID: PRTN3_HUMAN
Immunogen: Capture immunogen: Recombinant Human PR3 protein.
Detection Immunogen: Recombinant Human PR3 protein.
Function Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Protein Name Myeloblastin
Agp7
C-Anca Antigen
Leukocyte Proteinase 3
Pr-3
Pr3
Neutrophil Proteinase 4
Np-4
P29
Wegener Autoantigen
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-449836
Reactome: R-HSA-6798695
Reactome: R-HSA-6803157
Cellular Localisation Cytoplasmic Granule
Secreted
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Membrane Raft
Localizes Predominantly To Azurophil Granules (Primary Secretory Granules) In Neutrophils
Secreted Upon Neutrophil Stimulation By Tnf-Alpha
Lipopolysaccharide (Lps)
Fmlp And Cxcl8/Il8 Or During Neutrophil Transmigration
Following Secretion Tethered To The Cell Membrane By Cd177
Alternative Antibody Pair Names Myeloblastin antibody pair
Agp7 antibody pair
C-Anca Antigen antibody pair
Leukocyte Proteinase 3 antibody pair
Pr-3 antibody pair
Pr3 antibody pair
Neutrophil Proteinase 4 antibody pair
Np-4 antibody pair
P29 antibody pair
Wegener Autoantigen antibody pair
PRTN3 antibody pair
MBN antibody pair

Information sourced from Uniprot.org

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