Human PQBP1 protein (Recombinant) (N-His) (STJP003326)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PQBP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PQBP1 |
| Gene ID | 10084 |
| Uniprot ID | PQBP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp265 |
Additional Info
| Function | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. |
| Protein Name | Polyglutamine-Binding Protein 1Pqbp-138 Kda Nuclear Protein Containing A Ww DomainNpw38Polyglutamine Tract-Binding Protein 1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmic GranuleColocalizes With Srsf2 In Nuclear SpecklesColocalized With Pou3f2Colocalized With Atxn1 In Nuclear Inclusion BodiesLocalizes To Cytoplasmic Stress Granules |
| Alternative Protein Names | Polyglutamine-Binding Protein 1 proteinPqbp-1 protein38 Kda Nuclear Protein Containing A Ww Domain proteinNpw38 proteinPolyglutamine Tract-Binding Protein 1 proteinPQBP1 proteinNPW38 proteinJM26 protein |
Information sourced from Uniprot.org