Human PQBP1 protein (Recombinant) (His-Tag) (STJP017651)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PQBP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PQBP1 |
| Gene ID | 10084 |
| Uniprot ID | PQBP1_HUMAN |
| Accession Number | NP_005701.1 |
| Immunogen | Human |
| Immunogen Region | 1-265aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. |
| Function | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. |
| Protein Name | Polyglutamine-Binding Protein 1Pqbp-138 Kda Nuclear Protein Containing A Ww DomainNpw38Polyglutamine Tract-Binding Protein 1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmic GranuleColocalizes With Srsf2 In Nuclear SpecklesColocalized With Pou3f2Colocalized With Atxn1 In Nuclear Inclusion BodiesLocalizes To Cytoplasmic Stress Granules |
| Alternative Protein Names | Polyglutamine-Binding Protein 1 proteinPqbp-1 protein38 Kda Nuclear Protein Containing A Ww Domain proteinNpw38 proteinPolyglutamine Tract-Binding Protein 1 proteinPQBP1 proteinNPW38 proteinJM26 protein |
Information sourced from Uniprot.org