Human PPP6C protein (Recombinant) (N-His) (STJP010613)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PPP6C-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PPP6C |
| Gene ID | 5537 |
| Uniprot ID | PPP6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Leu305 |
Additional Info
| Function | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it. |
| Protein Name | Serine/Threonine-Protein Phosphatase 6 Catalytic SubunitPp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-204005 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Protein Names | Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit proteinPp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed proteinPPP6C proteinPPP6 protein |
Information sourced from Uniprot.org