Human PPBP/CXCL7/NAP-2 protein (Recombinant) (C-His) (STJP013078)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PPBP/CXCL7/NAP-2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM HAc-Nac, 150mM NaCl, pH 4.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | PPBP |
| Gene ID | 5473 |
| Uniprot ID | CXCL7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser35-Asp128 |
Additional Info
| Function | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. |
| Protein Name | Platelet Basic ProteinPbpC-X-C Motif Chemokine 7Leukocyte-Derived Growth FactorLdgfMacrophage-Derived Growth FactorMdgfSmall-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide IiiCtap-IiiLa-Pf4Low-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81Ctap-Iii(1-81 - Beta-ThromboglobulinBeta-Tg - Neutrophil-Activating Peptide 2(74Nap-2(74 - Neutrophil-Activating Peptide 2(73Nap-2(73 - Neutrophil-Activating Peptide 2Nap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66Nap-2(1-66 - Neutrophil-Activating Peptide 2(1-63Nap-2(1-63 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Platelet Basic Protein proteinPbp proteinC-X-C Motif Chemokine 7 proteinLeukocyte-Derived Growth Factor proteinLdgf proteinMacrophage-Derived Growth Factor proteinMdgf proteinSmall-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide Iii proteinCtap-Iii proteinLa-Pf4 proteinLow-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81 proteinCtap-Iii(1-81 - Beta-Thromboglobulin proteinBeta-Tg - Neutrophil-Activating Peptide 2(74 proteinNap-2(74 - Neutrophil-Activating Peptide 2(73 proteinNap-2(73 - Neutrophil-Activating Peptide 2 proteinNap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66 proteinNap-2(1-66 - Neutrophil-Activating Peptide 2(1-63 proteinNap-2(1-63 proteinPPBP proteinCTAP3 proteinCXCL7 proteinSCYB7 proteinTGB1 proteinTHBGB1 protein |
Information sourced from Uniprot.org