Human PP2C alpha/PPM1A protein (Recombinant) (His-Tag) (STJP019729)

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STJP019729
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Short Description :Recombinant-Human PP2C alpha/PPM1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 10mM Tris-HCl buffer (pH 7.5) containing 50mM NaCl, 2mM DTT, 1mM MnCl2, 20%Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Specific activity is > 1, 400unit/mg, and is defined as the amount of enzyme that hydrolyze 1.0nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.
Gene Symbol:PPM1A
Gene ID:5494
Uniprot ID:PPM1A_HUMAN
Accession Number:NP_066283
Immunogen:Human
Immunogen Region:1-382aa
Immunogen Sequence:MGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGS
Post Translational Modifications N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Protein Name Protein Phosphatase 1a
Protein Phosphatase 2c Isoform Alpha
Pp2c-Alpha
Protein Phosphatase Ia
Database Links Reactome: R-HSA-2173795
Reactome: R-HSA-380972
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Membrane
Lipid-Anchor
Weakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization
Alternative Protein Names Protein Phosphatase 1a protein
Protein Phosphatase 2c Isoform Alpha protein
Pp2c-Alpha protein
Protein Phosphatase Ia protein
PPM1A protein
PPPM1A protein

Information sourced from Uniprot.org

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