Human POMC protein (Recombinant) (N-GST & C-His) (STJP011266)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human POMC-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | POMC |
| Gene ID | 5443 |
| Uniprot ID | COLI_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala169-Glu267 |
Additional Info
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated.reducing sugar is probably N-acetylgalactosamine. |
| Function | Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. |
| Protein Name | Pro-OpiomelanocortinPomcCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin GammaGamma-Msh - Potential Peptide - CorticotropinAdrenocorticotropic HormoneActh - Melanocyte-Stimulating Hormone AlphaAlpha-MshMelanotropin Alpha - Corticotropin-Like Intermediary PeptideClip - Lipotropin BetaBeta-Lph - Lipotropin GammaGamma-Lph - Melanocyte-Stimulating Hormone BetaBeta-MshMelanotropin Beta - Beta-Endorphin - Met-Enkephalin |
| Database Links | Reactome: R-HSA-111885Reactome: R-HSA-193048Reactome: R-HSA-194002Reactome: R-HSA-202040Reactome: R-HSA-209952Reactome: R-HSA-211976Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-5579031Reactome: R-HSA-6785807Reactome: R-HSA-9615017Reactome: R-HSA-9856649 |
| Cellular Localisation | SecretedMelanocyte-Stimulating Hormone Alpha And Beta-Endorphin Are Stored In Separate Granules In Hypothalamic Pomc NeuronsSuggesting That Secretion May Be Under The Control Of Different Regulatory Mechanisms |
| Alternative Protein Names | Pro-Opiomelanocortin proteinPomc proteinCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma proteinGamma-Msh - Potential Peptide - Corticotropin proteinAdrenocorticotropic Hormone proteinActh - Melanocyte-Stimulating Hormone Alpha proteinAlpha-Msh proteinMelanotropin Alpha - Corticotropin-Like Intermediary Peptide proteinClip - Lipotropin Beta proteinBeta-Lph - Lipotropin Gamma proteinGamma-Lph - Melanocyte-Stimulating Hormone Beta proteinBeta-Msh proteinMelanotropin Beta - Beta-Endorphin - Met-Enkephalin proteinPOMC protein |
Information sourced from Uniprot.org