Human POMC protein (Recombinant) (His-Tag) (STJP017223)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human POMC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 1mM DTT, 50% Glycerol, 0.2M NaCl, 0.1mM PMSF, 100mM Imidazole |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POMC |
| Gene ID | 5443 |
| Uniprot ID | COLI_HUMAN |
| Accession Number | NP_001030333 |
| Immunogen | Human |
| Immunogen Region | 27-267aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | ACTH and MSH are produced by the pituitary gland. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated.reducing sugar is probably N-acetylgalactosamine. |
| Function | Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. |
| Protein Name | Pro-OpiomelanocortinPomcCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin GammaGamma-Msh - Potential Peptide - CorticotropinAdrenocorticotropic HormoneActh - Melanocyte-Stimulating Hormone AlphaAlpha-MshMelanotropin Alpha - Corticotropin-Like Intermediary PeptideClip - Lipotropin BetaBeta-Lph - Lipotropin GammaGamma-Lph - Melanocyte-Stimulating Hormone BetaBeta-MshMelanotropin Beta - Beta-Endorphin - Met-Enkephalin |
| Database Links | Reactome: R-HSA-111885Reactome: R-HSA-193048Reactome: R-HSA-194002Reactome: R-HSA-202040Reactome: R-HSA-209952Reactome: R-HSA-211976Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-5579031Reactome: R-HSA-6785807Reactome: R-HSA-9615017Reactome: R-HSA-9856649 |
| Cellular Localisation | SecretedMelanocyte-Stimulating Hormone Alpha And Beta-Endorphin Are Stored In Separate Granules In Hypothalamic Pomc NeuronsSuggesting That Secretion May Be Under The Control Of Different Regulatory Mechanisms |
| Alternative Protein Names | Pro-Opiomelanocortin proteinPomc proteinCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma proteinGamma-Msh - Potential Peptide - Corticotropin proteinAdrenocorticotropic Hormone proteinActh - Melanocyte-Stimulating Hormone Alpha proteinAlpha-Msh proteinMelanotropin Alpha - Corticotropin-Like Intermediary Peptide proteinClip - Lipotropin Beta proteinBeta-Lph - Lipotropin Gamma proteinGamma-Lph - Melanocyte-Stimulating Hormone Beta proteinBeta-Msh proteinMelanotropin Beta - Beta-Endorphin - Met-Enkephalin proteinPOMC protein |
Information sourced from Uniprot.org