Human PLXNB1 protein (Recombinant) (N-His) (STJP011430)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PLXNB1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PLXNB1 |
| Gene ID | 5364 |
| Uniprot ID | PLXB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys1067-Asp1251 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. |
| Function | Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. |
| Protein Name | Plexin-B1Semaphorin Receptor Sep |
| Database Links | Reactome: R-HSA-416482Reactome: R-HSA-416550Reactome: R-HSA-416572Reactome: R-HSA-9013405 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Protein Names | Plexin-B1 proteinSemaphorin Receptor Sep proteinPLXNB1 proteinKIAA0407 proteinPLXN5 proteinSEP protein |
Information sourced from Uniprot.org