Human PLOD3 protein (Recombinant) (N-His) (STJP007395)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PLOD3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PLOD3 |
| Gene ID | 8985 |
| Uniprot ID | PLOD3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn35-Asn255 |
Additional Info
| Function | Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine. Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes. |
| Protein Name | Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3Lysyl Hydroxylase 3Lh3 - Procollagen GlycosyltransferaseGalactosylhydroxylysine-GlucosyltransferaseProcollagen GalactosyltransferaseProcollagen Glucosyltransferase |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Rough Endoplasmic ReticulumEndoplasmic Reticulum LumenEndoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideSecretedExtracellular SpaceThe Majority Of The Secreted Protein Is Associated With The Extracellular Matrix |
| Alternative Protein Names | Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3 proteinLysyl Hydroxylase 3 proteinLh3 - Procollagen Glycosyltransferase proteinGalactosylhydroxylysine-Glucosyltransferase proteinProcollagen Galactosyltransferase proteinProcollagen Glucosyltransferase proteinPLOD3 protein |
Information sourced from Uniprot.org