Human PLIN5 (Perilipin 5) Sandwich ELISA Kit (STJE0011555)
SPECIFICATIONS
General Information
| Short Description | This PLIN5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.065ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | PLIN5 |
| Gene ID | 440503 |
| Uniprot ID | PLIN5_HUMAN |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle, liver, heart and kidney. |
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation. |
| Function | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. |
| Protein Name | Perilipin-5Lipid Storage Droplet Protein 5 |
| Database Links | |
| Cellular Localisation | Lipid DropletCytoplasmMitochondrionLipid Droplet Surface-AssociatedExchanges Between Lipid Droplets And The Cytoplasm |
| Alternative ELISA Names | Perilipin-5 ELISA kitLipid Storage Droplet Protein 5 ELISA kitPLIN5 ELISA kitLSDP5 ELISA kitOXPAT ELISA kitPAT-1 ELISA kit |
| output |
Information sourced from Uniprot.org