Human Plexin B1 (Plexin B1) Antibody Pair (STJAP00905)
General Information
| Short Description | This Plexin B1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R08-4C-9/R02-6R-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PLXNB1 |
| Gene ID | 5364 |
| Uniprot ID | PLXB1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. |
| Function | Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. |
| Protein Name | Plexin-B1Semaphorin Receptor Sep |
| Database Links | Reactome: R-HSA-416482Reactome: R-HSA-416550Reactome: R-HSA-416572Reactome: R-HSA-9013405 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Antibody Pair Names | Plexin-B1 antibody pairSemaphorin Receptor Sep antibody pairPLXNB1 antibody pairKIAA0407 antibody pairPLXN5 antibody pairSEP antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Plexin B1 (Plexin B1) Antibody Pair (STJAP00905)
This antibody pair detects human Plexin B1 (UniProt O43157) and has confirmed reactivity against the human protein only. No cross-reactivity with other species has been stated in the product details.
This antibody pair has been validated for use in ELISA. No other assay formats are listed as validated applications.
Both antibodies are rabbit monoclonal IgGs supplied in unconjugated format, formulated in 0.01M PBS at pH 7.2. The two clones are R08-4C-9 and R02-6R-2, and both were raised against a recombinant protein immunogen and purified by affinity chromatography.
Optimal working concentrations are to be determined by the end user, as no fixed dilution range is provided in the product details. Titration experiments are recommended to establish the appropriate concentrations for a given experimental setup.
The antibodies should be stored at 4°C for short-term use. For long-term storage, they should be aliquoted and kept at -20°C, with repeated freeze/thaw cycles avoided to maintain activity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.